Myelodysplastic SyndromeAuthor :
Hardback
Published : Wednesday 22 July 2020
Description
In this compilation, the authors review the biological aspects of myelodysplastic syndrome disease, diagnosis, and treatment, as well as innovations involving genetics and new treatment perspectives. Myelodysplastic syndromes are a heterogeneous group of clonal haematopoietic stem cells disorders characterized by dysplasia, as well as peripheral blood cytopenias with a hypercellular marrow and ineffective hematopoiesis. Myelodysplastic syndromes are frequently associated with acute and chronic inflammation, and autoimmune disorders such as: rheumatoid arthritis, bowel disease, diverse types of vasculitis, autoimmune anemias, several rheumatic and skin disorders, and certain thyroid disorders. Spliceosome mutations are the most frequent mutations found in blood and bone marrow cells of myelodysplastic syndromes patients. As such, the authors explore the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1, ZRSR2. Subsequently, this collection discusses the CSNK1A1 gene in the context of myelodysplastic syndromes. It is located at 5q32 within the deleted region, which encodes for casein kinase 1I+/- (CK1I+/-). CK1I+/- is a component of a multiprotein I(2)-catenin destruction complex that regulates Wnt/I(2)-catenin and p53 pathways. The concluding study focuses on the mutations in epigenetic modifiers occur which myelodysplastic syndromes and drive this disease, such as: DNA methylation, histone acetylation, and RNA interference that alters gene expression.
You may also like ...
by
Paperback
29 Aug 2024
Childrens / Teenage fiction: Humorous stories
€11.69
by
Hardback
02 May 2024
Birthing methods
€19.88
Extended stock – Dispatch 5-7 days
by
Hardback
18 Jan 2024
Gift books
€9.35
Extended stock – Dispatch 5-7 days
by
Hardback
02 Nov 2023
Picture storybooks
€15.20
Extended stock – Dispatch 5-7 days
Reviews